Lior Dangoor, 33y, diagnosed 06/07, RCC, clear cell, Stage IV, grade 3.
Mets to opposite (right) adrenal, spine, ribs, pelvis, lungs.
 
6.8
2014
 

History

28.6.07

  CT performed due to broken rib of unknown origin and spinal pain. Findings are: mass in left kidney (7.3×8.5×8.5cm), a mass in right adrenal (12×7x9cm), multiple bone metastases (posterior right 9th rib – with soft tissue – anterior right 5th rib, D7, D10, D11, L4, L5, sacrum, left iliac bone)  and several lung nodules. Significant cord compression at the level of D10 was diagnosed.
Biopsy from the kidney demonstrates Fuhrman’s nuclear grade 3, clear cell carcinoma, with positive staining for Vimentin, CD10, EMA. Areas of necrosis.

4.7.07

  Irradiation of spine at 3Gy (10 days). Begins treatment of Zometa monthly.

19.7.07

  First cycle of Sutent (50mg/28 days). CT at end of cycle shows significant shrinkage of renal and adrenal masses (30% and 40%). Shrinkage in lung lesions. Stability in bones.

28.8.07

  Sutent cycle 2. Additional slight shrinkage in soft tissue, stability in bones.

5.10.07

  Sutent cycle 3. Stability.

8.11.07

  Irradiation to both rib metastases at 3Gy (10 days).

14.11.07

  Sutent cycle 4. Stability.

20.12.07

  Surgery: Partial left nephrectomy and right adrenalectomy. Primary tissue culture cells grown and frozen.

7.1.08

  Sutent cycle 5. Only one lung nodule left. Bones stable, shrinkage in soft celebrity porn pictures tissue near 9th rib.

13.1.08

  HLA typing reveals that one of Lior’s sisters has similar HLA type (and can be a donor if stem cell transplant becomes an option).

15.2.08

  Sutent cycle 6. Near total disappearance of lung nodules.

26.2,08

  Pathology staining at UCLA demonstrates tumor cells positive for Carbonic Anhydrase IX (CA IX) in over 95% of the cells and Furhman grade 2 – not 3.

27.3-18.4.08

  High Dose Interleukin-2. Two rounds. 8 and 9 doses.

4.5,08

  Sutent cycle 7.

30.5.08

  MRI demonstrates bone metastases are still active and suggests – in addition to increase in ESR and platelet levels seen only in 07.07 and reappearance of sever thoracic back pain immediately after HD IL-2 – that IL-2 did not have a significant anti-tumoral effect.

12.6.08

  Sutent cycle 8.

20.7.08

  Sutent cycle 9.

18.8.08

  CT scan shows no new findings and sclerotic process (early bone formation) in a number of bone sites.

28.8.08

  Sutent cycle 10.

28.9.08

  MRI shows that all bone metastases are still active though perhaps less. This scan covers the femur for the first time and demonstrates a “new” finding in right femur. A look back at older CT scans confirms that this met was there since the beginning.

11.10.08

  Sutent cycle 11. CT shows stability in all sites.

20.11.08

  Sutent cycle 12.

28.12.08

  Sutent cycle 13. CT shows stability in all sites.

25.01.09

  First dose of DNP-modified autologous vaccine.

02.02.09

  Sutent cycle 14.

19.02.09

  Second dose of DNP-modified autologous vaccine.

12.03.09

  Third dose of DNP-modified autologous vaccine.

13.03.09

  Sutent cycle 15. CT shows stability in all sites.

02.04.09

  Fourth dose of DNP-modified autologous vaccine.

21.04.09

  Fifth dose of DNP-modified autologous vaccine. A skin test to evaluate delayed-type hypersensitivity (DTH) to the autologous cancer cells was performed by injecting unmodified irradiated cancer cells. A weak response (1+) was attained.

22.04.09

  Sutent cycle 16.

21.05.09

Sixth dose of DNP-modified autologous vaccine.

31.05.09

Sutent cycle 17.
 
 

 
26.10.09
   
WBC2.2
Hemoglobin11.6
Platelets187
Creatinine0.8
CRP1.7
ESR90
CA 15.331.3
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