Lior Dangoor, 33y, diagnosed 06/07, RCC, clear cell, Stage IV, grade 3.
Mets to opposite (right) adrenal, spine, ribs, pelvis, lungs.
 
6.8
2014
 

Immunologic and clinical effects of antibody blockade

Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients
F. Stephen Hodi, Marcus Butler, Darryl A. Oble, Michael V. Seiden, Frank G. Haluska,
Andrea Kruse, Suzanne MacRae, Marybeth Nelson, Christine Canning, Israel Lowy, Alan Korman, David Lautz, Sara Russell, Michael T. Jaklitsch, Nikhil Ramaiya, Teresa C. Chen, Donna Neuberg, James P. Allison, Martin C. Mihm, and Glenn Dranoff,
PNAS, 105(8): 3005-3010, February 2008

Abstract

Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) functions as a negative regulator of endogenous and vaccine-induced antitumor immunity. The administration of fully human anti-CTLA-4 blocking monoclonal antibodies to advanced-cancer patients increases immune-mediated tumor destruction in some subjects. Nonetheless, patients that respond also frequently manifest serious inflammatory pathologies, raising the possibility that the therapeutic and toxic effects of CTLA-4 blockade might be linked. Here we show that periodic infusions of anti-CTLA-4 antibodies after vaccination with irradiated, autologous tumor cells engineered to secrete GM-CSF (GVAX) generate clinically meaningful antitumor immunity without grade 3 or 4 toxicity in a majority of metastatic melanoma patients. The application of this sequential immunotherapy to advanced ovarian carcinoma patients also revealed that tumor destruction and severe inflammatory pathology could be dissociated, although further refinements are required to increase clinical responses and to minimize toxicity in this population. The extent of therapy-induced tumor necrosis was linearly related to the natural logarithm of the ratio of intratumoral CD8+ effector T cells to FoxP3+ regulatory T cells (Tregs) in posttreatment biopsies. Together, these findings help clarify the immunologic and clinical effects of CTLA-4 antibody blockade in previously vaccinated patients and raise the possibility that selective targeting of antitumor Tregs may constitute a complementary strategy for combination therapy.

Full Article | celebrity sex tapes Back To Index

 
 

 
26.10.09
   
WBC2.2
Hemoglobin11.6
Platelets187
Creatinine0.8
CRP1.7
ESR90
CA 15.331.3
The Official Beatles Website Sipur Pashut Book Store בצק אלים- הבלוג למתכונים
מרתה סטיוארט
החנות של מוג'י
אוליה - בוטיק למוצרי שמן זית #
# #
#
#
CREATED BY
RER
 
  Powered by WordPress